The vertebrate zebrafish is a promising model for identification of developmental toxicants. Its small size and rapid embryonic development allow for high throughput screening of large numbers of chemicals. I will discuss two screens that we have recently performed: screening for (1) vascular disruptors and for (2) chemicals that perturb the development of neuromast cells. Zebrafish neuromasts are mechanosensory cells that responds to the flow of water, and they are structurally and functionally similar to human inner ear hair cells. We used transgenic zebrafish embryos expressing fluorescence in vascular endothelial cells or neuromasts to screen for compounds that interfere with the development of these tissues. From EPA’s ToxCast phase I chemical library of 294 compounds, we identified around 20 vascular and neuromast disruptors, and their lowest effect levels (LELs) were determined. Computational toxicology was used to predict modes of actions of the compounds. Some of these predictions were experimentally confirmed. This suggests that the developing zebrafish embryo is an efficient in vivo model that can be used for rapid identification of compounds interfering with embryonic development, and has the potential to be developed into a predictive toxicity model.